3D conservative-field test
A vector field in space is conservative on a simply connected region exactly when its curl is zero everywhere.
The 3D upgrade of the 2D cross-partials check packages all three cross-partial comparisons into a single vector condition: \operatorname{curl}\mathbf{F}=\mathbf{0}. \mathbf{F}=\nabla f \Rightarrow \operatorname{curl}\mathbf{F}=\mathbf{0} holds unconditionally everywhere, by Clairaut's Theorem. The converse needs the region to be simply connected in the 3D sense — every closed curve inside it must be shrinkable to a point without leaving the region — which is a stronger condition than merely having no missing volume (a solid doughnut has no missing chunk of volume but is not simply connected, since a loop through its hole can't shrink).
Examples
For \mathbf{F}(x,y,z) = (yz,\, xz,\, xy) on \mathbb{R}^3 (simply connected): \operatorname{curl}\mathbf{F}=\mathbf{0}, so \mathbf{F} is conservative, with potential function f(x,y,z) = xyz.