comma that sets off
The comma (or comma pair) marking the boundary of something nonessential to the sentence's core meaning.
A comma that sets off marks the boundary of material that is not essential to a sentence's core meaning — an introductory element, a nonessential description in the middle of a sentence, or an appositive — using one comma if the material comes at the start or end and a pair if it interrupts the middle.
Examples
After the meeting, we grabbed lunch.
My brother, who lives in Denver, is visiting.